Tags: agent  antineoplastic  cancer  ganja  glioma  marijuana  medical  nc420reform  pot  reefer  research  
Channel: Education
Uploaded: December 31, 1969 at 6:59 pm
Author: NC420Reform
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Glioma Research (click more for details)A review of the modern scientific literature reveals numerous preclinical studies and one pilot clinical study demonstrating cannabinoids' ability to act as antineoplastic agents, particularly on glioma cell lines. Writing in the September 1998 issue of the journal FEBS Letters, investigators at Madrid's Complutense University, School of Biology, first reported that delta-9-THC induced apoptosis (programmed cell death) in glioma cells in culture.[1] Investigators followed up their initial findings in 2000, reporting that the administration of both THC and the synthetic cannabinoid agonist WIN 55,212-2 "induced a considerable regression of malignant gliomas" in animals.[2] Researchers again confirmed cannabinoids' ability to inhibit tumor growth in animals in 2003.[3]That same year, Italian investigators at the University of Milan, Department of Pharmacology, Chemotherapy and Toxicology, reported that the non-psychoactive cannabinoid, cannabidiol (CBD), inhibited the growth of various human glioma cell lines in vivo and in vitro in a dose dependent manner. Writing in the November 2003 issue of the Journal of Pharmacology and Experimental Therapeutics Fast Forward, researchers concluded, "Non-psychoactive CBD ... produce[s] a significant anti-tumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent."[4]To see this text in full: http://www.norml.org/index.cfm... Author:For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds.Paul ArmentanoDeputy Director NORML | NORML FoundationWashington, DCJanuary 24, 2008* The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report.** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation. http://norml.com/index.cfm?Gro... beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840